Tetramethylammonium Fluoride: Fundamental Properties and Applications in C-F Bond-Forming Reactions and as a Base

Nucleophilic ionic sources of fluoride are essential reagents in the synthetic toolbox to access high added-value fluorinated building blocks unattainable by other means. In this review, we provide a concise description and rationale outstanding features one these reagents, tetramethylammonium (TMAF), as well disclosing different methods for its preparation, how physicochemical properties solvation effects solvents intimately associated with reactivity. Furthermore, herein also comprehensively describe historic recent utilization, up December 2021, C-F bond-forming reactions special emphasis on nucleophilic aromatic substitution fluorinations potential sustainable application industrial settings, use base capable rendering unprecedented transformations.